Parthasarathy S, Santanam N, Augé N
Department of Gynecology and Obstetrics, Emory University, Atlanta, GA 30322, USA.
Biochem Pharmacol. 1998 Aug 1;56(3):279-84. doi: 10.1016/s0006-2952(98)00074-4.
The word antioxidant has become a household term, and every day we are bombarded with claims of antioxidant protection against a host of diseases. Atherosclerosis, cancer, gastric ulcers, memory loss, rheumatoid arthritis, endometriosis, pregnancy complications, hypertension, stroke, and a host of other diseases have been suggested to be induced by oxidative stress, and antioxidants have been suggested to be beneficial in the prevention and treatment of these disorders. While some of these may be exuberant claims, atherosclerosis is one disease in which the oxidation hypothesis has taken firm roots. The oxidation of low-density lipoprotein (LDL) has been suggested to be a key step in the initiation of the early atherosclerotic lesion. A number of proatherogenic effects have been described for both the protein and lipid components of oxidized low-density lipoprotein. In this commentary, a brief description of the involvement of oxidation and the potential for antioxidant treatment for cardiovascular disease will be provided. However, there are innumerable questions plaguing the hypothesis; this commentary, therefore, will also serve as a devil's advocate and propose that some form of oxidation might actually be beneficial.
“抗氧化剂”一词已成为家喻户晓的词汇，每天我们都会受到各种关于抗氧化剂能预防多种疾病的宣传的轰炸。动脉粥样硬化、癌症、胃溃疡、记忆力减退、类风湿性关节炎、子宫内膜异位症、妊娠并发症、高血压、中风以及许多其他疾病都被认为是由氧化应激引发的，而抗氧化剂被认为对这些疾病的预防和治疗有益。虽然其中一些说法可能有些夸张，但动脉粥样硬化是氧化假说已深深扎根的一种疾病。低密度脂蛋白（LDL）的氧化被认为是早期动脉粥样硬化病变起始的关键步骤。氧化型低密度脂蛋白的蛋白质和脂质成分都已被描述有许多促动脉粥样硬化作用。在这篇评论中，将简要描述氧化作用的参与情况以及抗氧化剂治疗心血管疾病的潜力。然而，这个假说存在无数问题；因此，这篇评论也将扮演唱反调的角色，并提出某种形式的氧化实际上可能是有益的。
