Bertschy G, Eap C B, Powell K, Baumann P
Département Universitaire de Psychiatrie Adulte, Lausanne, Switzerland.
Ther Drug Monit. 1996 Oct;18(5):570-2. doi: 10.1097/00007691-199610000-00008.
We report nine cases where fluoxetine (FX) (20 mg/day) was added to maintenance treatment with methadone (MTD) (dose range: 30-100 mg) in addicts with affective disorders. MTD plasma levels were measured before and after treatment with FX under steady-state conditions. Among the nine patients, two also received fluvoxamine (FLVX) at different times. Although it is possible that in some patients a moderate FX-MTD interaction occurs, resulting in increased plasma levels of MTD, this interaction is certainly less marked than that between FLVX and MTD and unlikely to have clinical consequences.
我们报告了9例在患有情感障碍的成瘾者中，将氟西汀（FX）（20毫克/天）添加到美沙酮（MTD）维持治疗（剂量范围：30 - 100毫克）中的病例。在稳态条件下，于FX治疗前后测定MTD的血浆水平。9例患者中有2例在不同时间还接受了氟伏沙明（FLVX）治疗。虽然在某些患者中可能会发生中等程度的FX - MTD相互作用，导致MTD血浆水平升高，但这种相互作用肯定不如FLVX与MTD之间的相互作用明显，并且不太可能产生临床后果。
