Goldman R G, Alexander G E, Zemishlany Z, Mukherjee S, Sackeim H, Prohovnik I
Department of Brain Imaging, New York State Psychiatric Institute, NY 10032, USA.
Biol Psychiatry. 1996 Oct 1;40(7):604-8. doi: 10.1016/0006-3223(95)00391-6.
To evaluate the effects of neuroleptic medications on cerebral blood flow (CBF), cortical perfusion was quantified by the 133xenon technique in 8 unmedicated schizophrenics and 9 healthy controls before, and 1 and 3 hours after, administration of haloperidol (5 mg per os). At 3 hours, the normal subjects, but not schizophrenic patients, showed a significant increase in global mean perfusion (17 +/- 13%). Changes in CBF were not associated with plasma haloperidol levels or the presence of extrapyramidal side effects, and remained significant after controlling for pCO2. The lack of change in CBF in schizophrenic patients following acute haloperidol administration may be due to prior neuroleptic exposure, absence of anxiety, or other nonspecific factors, or may reflect a more fundamental feature of underlying pathophysiology in schizophrenia.
为评估抗精神病药物对脑血流量（CBF）的影响，采用133氙技术对8例未服用药物的精神分裂症患者和9名健康对照者在口服氟哌啶醇（5毫克）之前、之后1小时和3小时的皮质灌注进行了量化。3小时时，正常受试者而非精神分裂症患者的全脑平均灌注显著增加（17±13%）。CBF的变化与血浆氟哌啶醇水平或锥体外系副作用的存在无关，在控制pCO2后仍具有显著性。急性给予氟哌啶醇后精神分裂症患者CBF缺乏变化可能是由于先前接触过抗精神病药物、不存在焦虑或其他非特异性因素，也可能反映了精神分裂症潜在病理生理学的更基本特征。
