Jäger A
Department of Orthodontics, University of Göttingen, Germany.
J Anat. 1996 Oct;189 ( Pt 2)(Pt 2):257-64.
To study age-related changes in human desmodontal bone remodelling, histological specimens were prepared from 42 human mandibles from individuals aged between 16 and 71 years which were obtained from autopsies. Microradiographs of horizontal ground sections and the corresponding undecalcified histological sections stained with Goldner trichrome were used for analysis. Histomorphometric measurements of static bone remodelling were performed along the desmodontal bone surface using a computer assisted semiautomatic measurement system. External influences from the individual dental occlusion and periodontal conditions were superimposed on age changes. A modest but significant age-dependent decrease in the surface extent of osteoid seams covered by 'active' osteoblasts was found. In addition, the number of osteoclasts per unit of resorptive bone surface diminished, leading to an increase in Howship's lacunae, devoid of osteoclasts. Both phenomena were interpreted as being due to a decrease in active bone forming capacity with age.
为研究人牙周膜骨重塑的年龄相关变化，从16至71岁个体的42例人下颌骨尸检标本制备了组织学标本。使用水平磨片的显微放射照片以及用Goldner三色染色的相应未脱钙组织学切片进行分析。使用计算机辅助半自动测量系统沿牙周膜骨表面进行静态骨重塑的组织形态计量学测量。个体牙咬合和牙周状况的外部影响叠加在年龄变化上。发现被“活跃”成骨细胞覆盖的类骨质缝的表面范围有适度但显著的年龄依赖性降低。此外，每单位吸收性骨表面的破骨细胞数量减少，导致没有破骨细胞的Howship陷窝增加。这两种现象都被解释为是由于随着年龄增长活跃骨形成能力下降所致。
