Maiorano E, Favia G, Ricco R
Institute of Pathological Anatomy, University of Bari, Italy.
J Oral Pathol Med. 1996 Jul;25(6):336-42. doi: 10.1111/j.1600-0714.1996.tb00273.x.
Sialadenoma papilliferum (SP) is a rare, benign, salivary gland tumor which most commonly arises in the palate. It has a typical biphasic gross and microscopic appearance which distinguishes this tumor from other papillary-like tumors of the oral cavity. This study reports the clinico-pathologic features of 5 new cases and analyzes the morphologic and immunophenotypic features of their cell components. Adluminal epithelial cells of duct-like structures appeared immunoreactive to cytokeratin 19 and to S-100 protein antibodies; two subsets of basally-located cells were identified by means of immunohistochemistry. One cell subset expressed cytokeratin 14, S-100 protein, GFAP, vimentin and smooth muscle actin immunoreactivity; this antigenic profile is consistent with myoepithelial differentiation. The second subset of basal cells expressed cytokeratins 13 and 14 reactivity but it was negative to all other antibodies. Anti-CD 1a and anti-S-100 protein antibodies revealed distinct cells with dendritic processes which resembled Langerhans cells. The extralobular location of SP, the continuity between neoplastic duct-like structures and the surface epithelium along with the presence, within the excretory ducts adjacent to the tumour, of lesions which possibly precede the development of SP give further strength to the hypothesis of an origin from the excretory ducts of this tumor. Langerhans cells seem to be present in sialadenoma papilliferum but their role in this tumor is still unclear.
乳头状涎腺瘤（SP）是一种罕见的良性涎腺肿瘤，最常见于腭部。它具有典型的大体和显微镜下双相表现，这使其与口腔其他乳头状肿瘤相区别。本研究报告了5例新病例的临床病理特征，并分析了其细胞成分的形态学和免疫表型特征。导管样结构的管腔内上皮细胞对细胞角蛋白19和S-100蛋白抗体呈免疫反应；通过免疫组织化学鉴定出两个位于基底的细胞亚群。一个细胞亚群表达细胞角蛋白14、S-100蛋白、GFAP、波形蛋白和平滑肌肌动蛋白免疫反应性；这种抗原谱与肌上皮分化一致。基底细胞的第二个亚群表达细胞角蛋白13和14反应性，但对所有其他抗体均呈阴性。抗CD1a和抗S-100蛋白抗体显示出具有树突状突起的独特细胞，类似于朗格汉斯细胞。SP的小叶外位置、肿瘤性导管样结构与表面上皮之间的连续性，以及在肿瘤附近排泄管内存在可能先于SP发生的病变，进一步支持了该肿瘤起源于排泄管的假说。朗格汉斯细胞似乎存在于乳头状涎腺瘤中，但其在该肿瘤中的作用仍不清楚。
