Klauschie J, Rose S R
University of Tennessee, Memphis, USA.
J Pediatr Endocrinol Metab. 1996 Mar-Apr;9(2):181-7.
To characterize heights and growth velocities of non-referred children with shunted hydrocephalus.
Accurate home height measurements of 94 subjects (age 1-18 yr); repeated in 54 after one year. Heights were compared with those of general population, and with sibling and target height.
31% were below population 5th percentile, 34% were short for target height, and 25% were short for siblings. Slow growth velocity was present in 41%. Short stature (SS) was present in 40% with concurrent medical problems, and in 24% with no such problems. Medical problems with increased risk of SS included spina bifida or meningomyelocele, Dandy Walker syndrome, brain tumor, cerebral palsy, epilepsy, impaired vision, mental retardation, and pulmonary disorders. Finally, history of premature birth, seen in 31%, led to higher incidence of SS for target height (54%) than did term birth (28%). Accelerated growth was present in 37%.
Children with hydrocephalus are at increased risk for short stature, slow growth velocity, or accelerated growth. Observation of premature entry to puberty, or accelerated or slow growth velocity should prompt an endocrine evaluation.
描述接受分流术治疗的脑积水患儿的身高及生长速度特征。
对94名受试者（年龄1 - 18岁）进行精确的家庭身高测量；一年后对其中54名进行复测。将身高与普通人群、同胞及靶身高进行比较。
31%低于人群第5百分位数，34%低于靶身高，25%低于同胞身高。41%生长速度缓慢。40%伴有其他疾病的患儿存在身材矮小（SS），无此类疾病的患儿中这一比例为24%。与身材矮小风险增加相关的疾病包括脊柱裂或脊髓脊膜膨出、丹迪-沃克综合征、脑肿瘤、脑瘫、癫痫、视力障碍、智力障碍及肺部疾病。最后，31%的患儿有早产史，其低于靶身高的发生率（54%）高于足月出生的患儿（28%）。37%生长加速。
脑积水患儿身材矮小、生长速度缓慢或生长加速的风险增加。观察到青春期提前、生长加速或生长速度缓慢应促使进行内分泌评估。
