Safieh-Garabedian B, Poole S, Allchorne A, Kanaan S, Saade N, Woolf C J
Department of Biology, American University of Beirut, Lebanon.
Neuropharmacology. 1996 May;35(5):599-603. doi: 10.1016/0028-3908(96)84630-2.
The effect of systemic zinc administration on the inflammatory hyperalgesia induced by intraplantar injections of either complete Freund's adjuvant (CFA) or bacterial endotoxin/lipopolysaccharide (LPS) in a hindpaw of adult rats was investigated. CFA injection resulted in mechanical and thermal hyperalgesia and an elevation in the levels of interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) in the ipsilateral hindpaw. Zinc treatment (20 nmole) significantly reduced sensitivity in the early phase of the inflammation and diminished the increase in the levels of IL-1 beta and NGF without affecting paw swelling. Intraplantar LPS injection also produced mechanical hyperalgesia and this too was reduced by zinc administration in a dose-dependent fashion (0.1-20 nmoles). Our results indicate that zinc has an analgesic action during early inflammation and that this may be the consequence of reducing levels of the inflammatory cytokine IL-beta and the growth factor NGF.
研究了全身性给予锌对成年大鼠后爪注射完全弗氏佐剂（CFA）或细菌内毒素/脂多糖（LPS）所诱导的炎性痛觉过敏的影响。注射CFA导致同侧后爪出现机械性和热痛觉过敏，并使白细胞介素-1β（IL-1β）和神经生长因子（NGF）水平升高。锌治疗（20纳摩尔）在炎症早期显著降低了敏感性，并减少了IL-1β和NGF水平的升高，而不影响爪肿胀。足底注射LPS也产生了机械性痛觉过敏，锌给药（0.1 - 20纳摩尔）也以剂量依赖的方式降低了这种痛觉过敏。我们的结果表明，锌在炎症早期具有镇痛作用，这可能是降低炎性细胞因子IL-β和生长因子NGF水平的结果。
