Gückel F J, Brix G, Schmiedek P, Piepgras Z, Becker G, Köpke J, Gross H, Georgi M
Institute for Clinical Radiology, Klinikum Mannheim, Fakultät für Klinische Medizin Mannheim, University of Heidelberg, Germany.
Radiology. 1996 Nov;201(2):405-12. doi: 10.1148/radiology.201.2.8888232.
To quantitatively assess cerebrovascular reserve capacity in patients with occlusive cerebrovascular disease.
In 21 symptomatic patients with occlusive cerebrovascular disease, magnetic resonance (MR) imaging was performed with a 1.5-T system. Before, during, and after a brief bolus injection of gadopentetate dimeglumine into the antecubital vain, a series of 32 rapid T2*-weighted gradient-echo images of two different sections were acquired simultaneously to measure the concentration-time-curves in the brain tissue and in the brain-feeding arteries. Principles of indicator dilution analysis were applied to compute regional cerebral blood flow (rCBF) and volume. Each patient underwent two examinations, the first before and the second after acetazolamide stimulation.
In the asymptomatic hemisphere, a mean increase in rCBF value of 47.1% was observed after acetazolamide stimulation. In the affected areas of the symptomatic hemisphere, a statistically significantly reduced response to acetazolamide stimulation was found, indicating a severely compromised cerebrovascular reserve capacity.
MR imaging with the described techniques provides quantitative information about the cerebrovascular reserve capacity in patients with occlusive cerebrovascular disease.
定量评估闭塞性脑血管疾病患者的脑血管储备能力。
对21例有症状的闭塞性脑血管疾病患者，采用1.5-T系统进行磁共振（MR）成像。在肘前静脉快速推注钆喷酸葡胺之前、期间和之后，同时采集两个不同层面的一系列32幅快速T2*加权梯度回波图像，以测量脑组织和脑供血动脉中的浓度-时间曲线。应用指示剂稀释分析原理计算局部脑血流量（rCBF）和血容量。每位患者接受两次检查，第一次在乙酰唑胺刺激前，第二次在乙酰唑胺刺激后。
在无症状半球，乙酰唑胺刺激后rCBF值平均增加47.1%。在有症状半球的受累区域，发现对乙酰唑胺刺激的反应在统计学上显著降低，表明脑血管储备能力严重受损。
采用所述技术的MR成像可提供有关闭塞性脑血管疾病患者脑血管储备能力的定量信息。
