Mattay V S, Weinberger D R, Barrios F A, Sobering G S, Kotrla K J, van Gelderen P, Duyn J H, Sexton R H, Moonen C T, Frank J A
Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD 20892.
Radiology. 1995 Mar;194(3):687-91. doi: 10.1148/radiology.194.3.7862963.
To compare directly the two most widely used methods of functional magnetic resonance (MR) imaging--dynamic contrast material-enhanced MR imaging and blood oxygenation level-dependent (BOLD) MR imaging.
Five healthy volunteers underwent dynamic contrast-enhanced and BOLD MR imaging with a conventional 1.5-T MR unit during visual stimulation and a dark control state. BOLD studies were performed with a gradient-echo sequence, and dynamic MR imaging was performed with an echo-shifted gradient-echo sequence after intravenous administration of a bolus of gadopentetate dimeglumine.
A significantly greater percentage signal change was found with dynamic MR imaging than with the BOLD technique. The extent of area activated was also significantly greater.
With standard clinical imagers and these gradient-echo-based techniques, greater percentage activation and area of activation can be achieved with dynamic MR imaging than with BOLD MR imaging.
直接比较两种最广泛使用的功能磁共振（MR）成像方法——动态对比剂增强MR成像和血氧水平依赖（BOLD）MR成像。
5名健康志愿者在视觉刺激和暗对照状态下，使用传统1.5-T MR设备接受动态对比增强和BOLD MR成像。BOLD研究采用梯度回波序列进行，动态MR成像在静脉注射钆喷酸葡胺团注后，采用回波移位梯度回波序列进行。
动态MR成像发现的信号变化百分比明显高于BOLD技术。激活区域的范围也明显更大。
使用标准临床成像仪和这些基于梯度回波的技术，动态MR成像比BOLD MR成像能实现更高的激活百分比和更大的激活面积。
