Johnson B A, Campling G M, Griffiths P, Cowen P J
Oxford University Department of Psychiatry, UK.
Psychopharmacology (Berl). 1993;112(1):142-4. doi: 10.1007/BF02247375.
We studied the effect of the 5-HT3 receptor antagonist ondansetron (4 mg orally) on some of the psychological effects of a small dose of alcohol (580 ml of 3.6% alcohol content by volume of lager) in 16 healthy male volunteers using a double-blind placebo controlled, Latin Square cross-over design. Pretreatment with ondansetron significantly attenuated several of the subjective pleasurable effects of alcohol, and also decreased the subjective desire to drink. These findings are consistent with preclinical studies suggesting that the reinforcing properties of alcohol may be attenuated by 5-HT3 receptor blockade.
我们采用双盲、安慰剂对照、拉丁方交叉设计，研究了5-羟色胺3（5-HT3）受体拮抗剂昂丹司琼（口服4毫克）对16名健康男性志愿者摄入小剂量酒精（580毫升酒精含量为3.6%的贮藏啤酒）后某些心理效应的影响。昂丹司琼预处理显著减弱了酒精的几种主观愉悦效应，还降低了主观饮酒欲望。这些发现与临床前研究一致，提示5-HT3受体阻断可能会减弱酒精的强化特性。
