Jacknowitz A I, Le Frock J L, Prince R A
Am J Hosp Pharm. 1977 Jul;34(7):759-62.
Two case reports of patients who developed a toxic neuropathy associated with nitrofurantoin are presented. In each case the patient had normal renal function and the symptoms abated upon withdrawal of the drug. Although the specific mechanism by which nitrofurantoin causes the neuropathy is still not known, various hypotheses are discussed and the literature is reviewed. The danger of nitrofurantoin administration in patients with impaired renal function is emphasized, and it is stress that early signs and symptoms of peripheral neuropathy be reported and the drug immediately discontinued. Even in the presence of normal renal function, the recommended dosage and duration of therapy should not be exceeded.
本文报告了两例与呋喃妥因相关的中毒性神经病患者。在每例病例中，患者肾功能正常，停药后症状缓解。尽管呋喃妥因导致神经病的具体机制尚不清楚，但讨论了各种假说并对文献进行了综述。强调了肾功能受损患者使用呋喃妥因的危险性，并强调应报告周围神经病的早期体征和症状并立即停药。即使肾功能正常，也不应超过推荐的剂量和疗程。
