Gasset A R
Am J Ophthalmol. 1977 Aug;84(2):169-71. doi: 10.1016/0002-9394(77)90849-2.
A 36-year-old woman fitted with a soft contact lens after an uneventful extracapsular cataract extraction was wearing her aphakic lens successfully until she switched her lens-soaking solution to an isotonic solution of boric acid, potassium chloride, and sodium carbonate preserved with benzalkonium chloride and edetic acid. After three days her eye became inflamed and vision decreased. No endothelial damage was apparent and the anterior chamber showed 2+ cell and flare reaction. Three weeks after removal of the lens and fitting with an aphakic lens visual acuity was 6/9 (20/30). Study of the preservative by a semiquantitative dilution method together with the clinical evidence in this case proved the cytotoxic effect of benzolkonium chloride when used to sterilize soft contact lenses.
一名36岁女性在顺利进行囊外白内障摘除术后佩戴软性隐形眼镜，一直成功佩戴无晶状体眼镜，直到她将镜片浸泡液换成含有苯扎氯铵和依地酸保存的硼酸、氯化钾和碳酸钠等渗溶液。三天后，她的眼睛发炎，视力下降。未发现明显的内皮损伤，前房显示2+细胞和闪光反应。摘除镜片并佩戴无晶状体眼镜三周后，视力为6/9（20/30）。通过半定量稀释法对防腐剂进行研究，并结合该病例的临床证据，证明了苯扎氯铵用于软性隐形眼镜消毒时的细胞毒性作用。
