自闭症儿童的肠道通透性异常。

Abnormal intestinal permeability in children with autism.

作者信息

D'Eufemia P, Celli M, Finocchiaro R, Pacifico L, Viozzi L, Zaccagnini M, Cardi E, Giardini O

机构信息

Institute of Pediatrics, La Sapienza University of Rome, Italy.

出版信息

Acta Paediatr. 1996 Sep;85(9):1076-9. doi: 10.1111/j.1651-2227.1996.tb14220.x.

DOI:10.1111/j.1651-2227.1996.tb14220.x

PMID:8888921

Abstract

We determined the occurrence of gut mucosal damage using the intestinal permeability test in 21 autistic children who had no clinical and laboratory findings consistent with known intestinal disorders. An altered intestinal permeability was found in 9 of the 21 (43%) autistic patients, but in none of the 40 controls. Compared to the controls, these nine patients showed a similar mean mannitol recovery, but a significantly higher mean lactulose recovery (1.64% +/- 1.43 vs 0.38% +/- 0.14; P < 0.001). We speculate that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormalities.

摘要

我们通过肠道通透性测试，对21名无与已知肠道疾病相符的临床及实验室检查结果的自闭症儿童进行了肠道黏膜损伤情况的测定。21名自闭症患者中有9名（43%）出现肠道通透性改变，而40名对照组儿童均未出现这种情况。与对照组相比，这9名患者的甘露醇平均回收率相似，但乳果糖平均回收率显著更高（分别为1.64%±1.43和0.38%±0.14；P<0.001）。我们推测，肠道通透性改变可能是食物来源的肽经肠道黏膜的通透性增加继而导致行为异常的一种潜在机制。