儿童肿瘤化疗期间的肠道通透性

Intestinal permeability during chemotherapy for childhood tumours.

作者信息

Pledger J V, Pearson A D, Craft A W, Laker M F, Eastham E J

机构信息

Department of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

出版信息

Eur J Pediatr. 1988 Feb;147(2):123-7. doi: 10.1007/BF00442208.

DOI:10.1007/BF00442208

PMID:3130249

Abstract

The intestinal permeability to mannitol and lactulose was measured in 29 children receiving treatment for solid tumours. At the time of study they had no gastrointestinal symptoms and appeared clinically well. However, there was a significant reduction in the absorption of mannitol when compared to normal children. This small bowel dysfunction may result in malabsorption of nutrients and drugs. There was a significant correlation between decreased mannitol absorption and low nutritional status.

摘要

对29名接受实体瘤治疗的儿童测量了其肠道对甘露醇和乳果糖的通透性。在研究时，他们没有胃肠道症状，临床状况良好。然而，与正常儿童相比，甘露醇的吸收显著减少。这种小肠功能障碍可能导致营养物质和药物吸收不良。甘露醇吸收减少与低营养状态之间存在显著相关性。