Wallace J L
Intestinal Disease Research Unit, University of Calgary, Alta.
Clin Invest Med. 1996 Oct;19(5):346-51.
The role of prostaglandins as mediators of gastrointestinal mucosal defence has been recognized for more than two decades. However, there is renewed interest in the potent actions of this group of fatty acids in modulating the mucosal immune system and inflammatory responses. Moreover, there is a rapidly growing body of evidence that nitric oxide is another important mediator of mucosal defence and the mucosal immune system. In this review, the effects of prostaglandins and nitric oxide on specific aspects of mucosal immunocyte function (e.g., mast cell reactivity) are reviewed, as is the evidence that these two groups of endogenous mediators cooperate in the modulation of mucosal defence.
前列腺素作为胃肠道黏膜防御介质的作用已被认识超过二十年。然而，人们对这类脂肪酸在调节黏膜免疫系统和炎症反应方面的强大作用重新产生了兴趣。此外，越来越多的证据表明一氧化氮是黏膜防御和黏膜免疫系统的另一个重要介质。在这篇综述中，我们回顾了前列腺素和一氧化氮对黏膜免疫细胞功能特定方面（如肥大细胞反应性）的影响，以及这两类内源性介质在调节黏膜防御中协同作用的证据。
