McCusker R H, Wangsness P J, Griel L C, Kavanaugh J F
Physiol Behav. 1985 Sep;35(3):383-8. doi: 10.1016/0031-9384(85)90313-0.
This study has indicated that temporal patterns of plasma GH changes were similar in lean and obese pigs with one to two secretory spikes occurring during a 6-hour period. Fasting caused increased GH in both pig strains; however, obese pigs, compared to lean, had lower GH during feeding and fasting. This depressed plasma GH of obese pigs may not be due entirely to impaired pituitary function since refeeding caused increased GH to levels similar to lean pigs. Insulin response per unit of feed intake was greater in obese pigs compared to lean. Together with higher insulin to glucose ratios, these results indicate hyperinsulinemia in the obese pigs. Overall, hormone and glucose responses were influenced by the nutritive status--fed, fasted or refed. Therefore consideration of feeding schedule was important in assessment of hormonal differences between the lean and obese pigs.
本研究表明，瘦猪和肥胖猪血浆生长激素（GH）变化的时间模式相似，在6小时期间出现一到两个分泌高峰。禁食使两种猪的GH水平升高；然而，与瘦猪相比，肥胖猪在进食和禁食期间的GH水平较低。肥胖猪血浆GH水平降低可能并不完全归因于垂体功能受损，因为再次喂食可使GH水平升高至与瘦猪相似的水平。与瘦猪相比，肥胖猪每单位采食量的胰岛素反应更大。这些结果与较高的胰岛素与葡萄糖比值一起，表明肥胖猪存在高胰岛素血症。总体而言，激素和葡萄糖反应受营养状态（进食、禁食或再次进食）的影响。因此，在评估瘦猪和肥胖猪之间的激素差异时，考虑喂食时间表很重要。
