Postema P T, den Haan P, van Hagen P M, van Blankenstein M
Department of Internal Medicine, Rotterdam University Hospital, The Netherlands.
Eur J Gastroenterol Hepatol. 1996 Sep;8(9):929-31.
A 40-year-old Turkish man on busulphan treatment for chronic myeloid leukaemia was hospitalized with steroid resistant (up to 100 mg prednisolone/24 h for over 4 weeks) colitis. On the basis of concomitant orogenital ulceration and unusual, deep punched out ulcers in the colon and smaller ulcers in the terminal ileum, Behçet's disease of the bowel, manifesting as ileocolitis, was diagnosed. Leukaemic infiltration, Crohn's colitis, neutropenic colitis and infectious colitis were excluded by histology and cultures. Treatment with colchicine 2 mg/day improved the orogenital ulcers but with only minor improvement of the colitis. Thalidomide treatment (400 mg/day), however, dramatically improved the colitis within 7 days: fever and diarrhoea disappearing. Colonoscopy after 4 weeks of treatment revealed previously giant ulcers practically healed.
一名40岁的土耳其男子因慢性粒细胞白血病接受白消安治疗，因患类固醇抵抗性（泼尼松龙100mg/24小时，持续4周以上）结肠炎住院。基于同时出现的口生殖器溃疡以及结肠内异常的深部凹陷性溃疡和回肠末端较小的溃疡，诊断为肠道白塞病，表现为回结肠炎症。通过组织学检查和培养排除了白血病浸润、克罗恩氏结肠炎、中性粒细胞减少性结肠炎和感染性结肠炎。每天服用2mg秋水仙碱治疗改善了口生殖器溃疡，但结肠炎仅有轻微改善。然而，沙利度胺治疗（400mg/天）在7天内使结肠炎显著改善：发热和腹泻消失。治疗4周后的结肠镜检查显示，之前的巨大溃疡几乎愈合。
