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Thalidomide and derivatives: immunological investigations of tumour necrosis factor-alpha (TNF-alpha) inhibition suggest drugs capable of selective gene regulation.沙利度胺及其衍生物：肿瘤坏死因子-α（TNF-α）抑制作用的免疫学研究表明，这些药物具有选择性基因调控能力。
Clin Exp Immunol. 1997 Nov;110(2):151-4. doi: 10.1111/j.1365-2249.1997.tb08310.x.
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Selective down-regulation of T cell- and non-T cell-derived tumour necrosis factor alpha by thalidomide: comparisons with dexamethasone.沙利度胺对T细胞和非T细胞来源的肿瘤坏死因子α的选择性下调作用：与地塞米松的比较
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Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester.沙利度胺可抑制由肿瘤坏死因子（TNF）和过氧化氢（H2O2）诱导的核因子κB（NF-κB）激活，但不能抑制由神经酰胺、脂多糖或佛波酯激活的NF-κB。
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Thalidomide in gastrointestinal disorders.
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Thalidomide analogue CC-3052 reduces HIV+ neutrophil apoptosis in vitro.沙利度胺类似物CC-3052可在体外减少HIV阳性中性粒细胞的凋亡。
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Anti-TNF antibody treatment of Crohn's disease.抗TNF抗体治疗克罗恩病。
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THALIDOMIDE IN THE TREATMENT OF LEPRA REACTIONS.沙利度胺治疗麻风反应
Clin Pharmacol Ther. 1965 May-Jun;6:303-6. doi: 10.1002/cpt196563303.
2
Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells.沙利度胺和地塞米松对人外周血单核细胞中细胞因子表达的差异调节
Immunopharmacology. 1998 Jul;40(1):11-20. doi: 10.1016/s0162-3109(98)00010-1.
3
Thalidomide therapy of established collagen-induced arthritis (CIA) not accompanied by an evident Th2 shift.沙利度胺治疗已确诊的胶原诱导性关节炎（CIA），且未伴有明显的Th2偏移。
Clin Exp Immunol. 1997 Jun;108(3):428-31. doi: 10.1046/j.1365-2249.1997.3781274.x.
4
Thalidomide as an anti-TNF-alpha inhibitor: implications for clinical use.
Clin Immunol Immunopathol. 1996 Dec;81(3):219-23. doi: 10.1006/clin.1996.0181.
5
Enantioselective inhibition of TNF-alpha release by thalidomide and thalidomide-analogues.沙利度胺及其类似物对肿瘤坏死因子-α释放的对映体选择性抑制作用。
Chirality. 1996;8(5):390-6. doi: 10.1002/(SICI)1520-636X(1996)8:5<390::AID-CHIR6>3.0.CO;2-I.
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Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis.NF-κB/Rel蛋白和细胞因子合成的生物学及生化抑制剂
Cytokine Growth Factor Rev. 1996 Aug;7(2):175-90. doi: 10.1016/1359-6101(96)00020-2.
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Treatment of colitis in Behçet's disease with thalidomide.沙利度胺治疗白塞病中的结肠炎
Eur J Gastroenterol Hepatol. 1996 Sep;8(9):929-31.
8
Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor alpha.对肿瘤坏死因子α的产生具有类似沙利度胺活性的苄基邻苯二甲酰亚胺和苯乙基邻苯二甲酰亚胺。
Biol Pharm Bull. 1995 Sep;18(9):1228-33. doi: 10.1248/bpb.18.1228.
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Augmentation by phthalimides of phorbol ester-induced expression of tumor necrosis factor alpha message.
Biol Pharm Bull. 1996 Jul;19(7):1001-3. doi: 10.1248/bpb.19.1001.
10
Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity.具有增强的肿瘤坏死因子α抑制活性的沙利度胺新型类似物的筛选。
Mol Med. 1996 Jul;2(4):506-15.

Thalidomide and derivatives: immunological investigations of tumour necrosis factor-alpha (TNF-alpha) inhibition suggest drugs capable of selective gene regulation.

作者信息

McHugh S M, Rowland T L

机构信息

Molecular Immunopathology Unit, Medical Research Council Centre, Cambridge, UK.

出版信息

Clin Exp Immunol. 1997 Nov;110(2):151-4. doi: 10.1111/j.1365-2249.1997.tb08310.x.

DOI:10.1111/j.1365-2249.1997.tb08310.x
PMID:9367395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2265499/
Abstract
摘要