人类成纤维细胞在体外产生“妊娠特异性”β-1糖蛋白。
Human fibroblasts produce "pregnancy-specific" beta-1 glycoprotein in vitro.
作者信息
Rosen S W, Kaminska J, Calvert I S, Aaronson S A
出版信息
Am J Obstet Gynecol. 1979 Aug 1;134(7):734-8. doi: 10.1016/0002-9378(79)90938-4.
PMID:88900
Abstract
Normal and genetic variant strains of nonmalignant human fibroblasts produce in vitro a substance indistinguishable from the recently described "pregnancy-specific" beta-1 glycoprotein (PSbetaG, PAPP-C, SP1). Demonstration of this presumed placenta-specific material in a nonplacental site raises questions about its normal physiologic role and use as a cancer marker.
摘要
非恶性人成纤维细胞的正常和基因变异株在体外产生一种物质，该物质与最近描述的“妊娠特异性”β-1糖蛋白（PSβG、PAPP-C、SP1）无法区分。在非胎盘部位发现这种推测为胎盘特异性的物质，引发了关于其正常生理作用以及作为癌症标志物用途的疑问。
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