文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lee R H, Heckman C J

Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611, USA.

J Neurophysiol. 1996 Sep;76(3):2107-10. doi: 10.1152/jn.1996.76.3.2107.

After application of the noradrenergic alpha 1 agonist methoxamine, muscle spindle Ia input evoked bistable firing patterns (i.e., persistent discharges after Ia input ceased) in adult spinal motoneurons in the decerebrate cat preparation. These bistable discharge patterns were compared with the Ia currents generated in voltage-clamp conditions. 2. During voltage clamp at depolarized holding potentials, the Ia effective synaptic current underwent strong amplification. In those cells with strong bistable firing, a prolonged tail current followed the Ia input. Because the voltage clamp held the behavior of somatic conductances constant, these data indicate that voltage-sensitive conductances in the motoneuron dendrites made an important contribution to bistable firing.

在应用去甲肾上腺素能α1激动剂甲氧明后，在去大脑猫制备中，肌肉梭Ia输入在成年脊髓运动神经元中诱发双稳态放电模式（即Ia输入停止后的持续放电）。将这些双稳态放电模式与电压钳制条件下产生的Ia电流进行比较。2. 在去极化钳制电位下进行电压钳制时，Ia有效突触电流经历了强烈放大。在那些具有强烈双稳态放电的细胞中，Ia输入后跟随有延长的尾电流。由于电压钳制使体细胞电导行为保持恒定，这些数据表明运动神经元树突中的电压敏感电导对双稳态放电起重要作用。

Lee R H, Heckman C J

Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611, USA.

J Neurophysiol. 1996 Sep;76(3):2107-10. doi: 10.1152/jn.1996.76.3.2107.

After application of the noradrenergic alpha 1 agonist methoxamine, muscle spindle Ia input evoked bistable firing patterns (i.e., persistent discharges after Ia input ceased) in adult spinal motoneurons in the decerebrate cat preparation. These bistable discharge patterns were compared with the Ia currents generated in voltage-clamp conditions. 2. During voltage clamp at depolarized holding potentials, the Ia effective synaptic current underwent strong amplification. In those cells with strong bistable firing, a prolonged tail current followed the Ia input. Because the voltage clamp held the behavior of somatic conductances constant, these data indicate that voltage-sensitive conductances in the motoneuron dendrites made an important contribution to bistable firing.

在应用去甲肾上腺素能α1激动剂甲氧明后，在去大脑猫制备中，肌肉梭Ia输入在成年脊髓运动神经元中诱发双稳态放电模式（即Ia输入停止后的持续放电）。将这些双稳态放电模式与电压钳制条件下产生的Ia电流进行比较。2. 在去极化钳制电位下进行电压钳制时，Ia有效突触电流经历了强烈放大。在那些具有强烈双稳态放电的细胞中，Ia输入后跟随有延长的尾电流。由于电压钳制使体细胞电导行为保持恒定，这些数据表明运动神经元树突中的电压敏感电导对双稳态放电起重要作用。