Jovell R J, Macario A J, Conway de Macario E
Wadsworth Center, Division of Molecular Medicine, New York State Department of Health, USA.
Gene. 1996 Oct 3;174(2):281-4. doi: 10.1016/0378-1119(96)00249-1.
Two genes, 5'-orfD-orfF-3', were found in the genome of the archaeon Methanosarcina mazei S-6 that encode the deduced proteins, OrfD and OrfF, with structural motifs typical of the nucleotide-binding components of the ABC-transporter systems of Bacteria and Eukarya. These motifs, and other similarities of OrfD and OrfF with bacterial and eukaryal counterparts, indicate that the two archaeal molecules belong to the ATP-binding cassette (ABC)-transporter family.
在马氏甲烷八叠球菌S-6古菌的基因组中发现了两个基因,5'-orfD-orfF-3',它们编码推导的蛋白质OrfD和OrfF,这些蛋白质具有细菌和真核生物ABC转运系统核苷酸结合成分典型的结构基序。这些基序,以及OrfD和OrfF与细菌和真核生物对应物的其他相似性,表明这两个古菌分子属于ATP结合盒(ABC)转运蛋白家族。