Pace A, Bove L, Nisticò C, Ranuzzi M, Innocenti P, Pietrangeli A, Terzoli E, Jandolo B
Neurology Service, Regina Elena National Cancer Institute, Rome, Italy.
J Neurol Neurosurg Psychiatry. 1996 Oct;61(4):409-11. doi: 10.1136/jnnp.61.4.409.
Vinorelbine (5'-noranhydrovinblastine) is a new semisynthetic antineoplastic vinca alkaloid which interfers with axonal transport, inducing spiralisation of axonal microtubules and resulting in peripheral neurotoxicity. A prospective detailed neurological and electrophysiological evaluation was performed in 23 patients treated with 25 mg vinorelbine a week. All patients developed a sensory-motor distal symmetric axonal neuropathy. The neurotoxicity increased with cumulative vinorelbine doses and peripheral neuropathy was mild or moderate in most patients. After discontinuation of vinorelbine treatment, neuropathic signs and symptoms were partially reversible.
长春瑞滨（5'-去甲脱水长春碱）是一种新型半合成抗肿瘤长春花生物碱，它干扰轴突运输，诱导轴突微管螺旋化，导致周围神经毒性。对23例每周接受25mg长春瑞滨治疗的患者进行了前瞻性详细的神经学和电生理学评估。所有患者均出现感觉运动性远端对称性轴索性神经病变。神经毒性随长春瑞滨累积剂量增加，大多数患者的周围神经病变为轻度或中度。停用长春瑞滨治疗后，神经病变的体征和症状部分可逆。
