Cormio G, Pellegrino A, Landoni F, Regallo M, Zanetta G, Colombo A, Mangioni C
III Department of Obstetrics and Gynecology, University of Milan, Italy.
Tumori. 1996 Jul-Aug;82(4):394-6. doi: 10.1177/030089169608200420.
Central nervous system (CNS) involvement by cervical carcinoma is uncommon. Out of 1,184 patients registered for invasive cervical carcinoma at our institution between 1982 and 1994, 14 (1.18%) developed brain metastases. Median age at the time of CNS metastasis diagnosis was 52 years. Median interval between diagnosis of cervical cancer and documentation of brain involvement was 18 months. Clinical manifestation included motor weakness, headache, seizures, dizziness and visual disturbances. All lesions (8 multiple, 6 single) were contrast enhanced on computerized tomography scans and were located in the cerebrum (n = 10), in the cerebellum (n = 2), or in both (n = 2). The CNS was the only site of detectable disease in 7 patients with recurrent disease. Eleven patients received only steroids, and 3 patients received radiotherapy. All 14 patients died, and median survival from diagnosis of brain metastases for the entire series was 4 months (range, 1-21). CNS metastases from cervical cancer are rare, and the prognosis for such patients appears poor.
宫颈癌累及中枢神经系统（CNS）并不常见。1982年至1994年间，在我们机构登记的1184例浸润性宫颈癌患者中，有14例（1.18%）发生了脑转移。CNS转移诊断时的中位年龄为52岁。宫颈癌诊断与脑转移记录之间的中位间隔时间为18个月。临床表现包括运动无力、头痛、癫痫发作、头晕和视觉障碍。所有病灶（8个多发，6个单发）在计算机断层扫描上均有强化，位于大脑（n = 10）、小脑（n = 2）或两者均有（n = 2）。在7例复发患者中，CNS是唯一可检测到疾病的部位。11例患者仅接受了类固醇治疗，3例患者接受了放疗。14例患者均死亡，整个系列从脑转移诊断后的中位生存期为4个月（范围1 - 21个月）。宫颈癌的CNS转移很少见，此类患者的预后似乎很差。
