Kanda M, Mima T, Xu X, Fujiwara N, Shindo K, Nagamine T, Ikeda A, Shibasaki H
Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.
Acta Neurol Scand. 1996 Aug;94(2):131-6. doi: 10.1111/j.1600-0404.1996.tb07043.x.
In 6 patients with Wallenberg's syndrome who showed a dissociated loss of pain sense, we recorded pain-related somatosensory evoked potentials following CO2 laser stimulation of the hand dorsum (pain SEPs). Two components, N2 and P2, were recorded by stimulation of the unaffected hand, whereas on the affected side they were absent or decreased in proportion to the severity of hypalgesia which was evaluated by both needle test and CO2 laser stimulation. Latency of either component, if appeared, was longer in the affected hand stimulation than that in the unaffected one. In contrast, N20 of the conventional electrically-stimulated SEPs (electric SEPs) showed no difference between the two sides. It is concluded that, unlike other electrophysiological methods, pain SEPs following CO2 laser stimulation can quantitatively evaluate functional impairment of the spinothalamic tract in Wallenberg's syndrome.
在6例表现出分离性痛觉丧失的延髓背外侧综合征患者中，我们记录了二氧化碳激光刺激手背（痛觉体感诱发电位）后的痛觉相关体感诱发电位。刺激未受影响的手时记录到两个成分，N2和P2，而在患侧，它们缺失或根据通过针刺试验和二氧化碳激光刺激评估的痛觉减退严重程度而降低。若任一成分出现，其在患侧手刺激时的潜伏期比未受影响侧更长。相比之下，传统电刺激体感诱发电位（电刺激诱发电位）的N20在两侧之间没有差异。得出的结论是，与其他电生理方法不同，二氧化碳激光刺激后的痛觉体感诱发电位可以定量评估延髓背外侧综合征中脊髓丘脑束的功能损害。
