Neuner-Jehle M, Denizot J P, Mallet J
Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, C.N.R.S. Bât. CERVI, Hôpital de la Pitié Salpêtrière, Paris, France.
Brain Res. 1996 Sep 9;733(1):149-54.
The rat protein kinase C substrate neurogranin has a granular distribution in cortical and hippocampal neurons. We demonstrate that in these cells, granular labelling corresponds to a local concentration of neurogranin-immunoreactivity at both the membranes of mitochondria and trans-Golgi vesicles and soma-proximal dendritic shaft and spinal head structures. Our findings suggest that the function of neurogranin could be affected by protein assembly at these cellular sites.
大鼠蛋白激酶C底物神经颗粒素在皮质和海马神经元中呈颗粒状分布。我们证明，在这些细胞中，颗粒状标记对应于神经颗粒素免疫反应性在线粒体膜、反式高尔基体囊泡以及胞体近端树突干和棘头结构处的局部富集。我们的研究结果表明，神经颗粒素的功能可能会受到这些细胞位点处蛋白质组装的影响。
