Anderson P J, Moss A L
Department of Craniofacial Surgery, Great Ormond Street Hospital, London, U.K.
Cleft Palate Craniofac J. 1996 Sep;33(5):436-9. doi: 10.1597/1545-1569_1996_033_0436_dfipoc_2.3.co_2.
The incidence of dental abnormalities in the cleft lip and palate population has been reported to be much higher than in the normal population. The role of genes in the production of a cleft lip and palate, and dental anomalies is thought to be complex, with autosomal dominant, recessive, and x-linked genes all playing a role. Noncleft parents can carry some of the cleft lip and palate genes, which produce clinically subtle manifestations in their facial skeleton. The purpose of this study was to look for evidence of increased dental anomalies in the non-cleft parents of cleft lip and palate children. The dentitions of the parents of 60 children with different types of cleft lip and palate were examined prospectively to see whether or not they exhibited features found more readily in the cleft lip and palate rather than did the normal population. Their dentitions were studied to record the following dental features: congenitally missing teeth, supernumerary teeth, or morphologic changes of the crowns of the permanent teeth. The number and position of any frenal attachments were also recorded. The results of this study did not show any differences in incidence of dental anomalies from the noncleft population. There was no evidence to support the hypothesis that congenital absence of lateral incisors is a microform of cleft lip and palate. Further, these results also failed to reveal any consistent pattern in the number and position of frenal attachments.
据报道，唇腭裂人群中牙齿异常的发生率远高于正常人群。基因在唇腭裂及牙齿异常形成过程中的作用被认为是复杂的，常染色体显性、隐性及X连锁基因均发挥作用。非唇腭裂父母可能携带某些唇腭裂基因，这些基因在其面部骨骼中产生临床上不易察觉的表现。本研究的目的是寻找唇腭裂患儿的非唇腭裂父母中牙齿异常增加的证据。前瞻性检查了60名不同类型唇腭裂患儿父母的牙列，以观察他们是否表现出在唇腭裂人群中比正常人群更易出现的特征。研究他们的牙列以记录以下牙齿特征：先天性缺牙、多生牙或恒牙冠形态改变。还记录了任何系带附着的数量和位置。本研究结果未显示牙齿异常发生率与非唇腭裂人群有任何差异。没有证据支持侧切牙先天性缺失是唇腭裂微小型的假说。此外，这些结果也未能揭示系带附着数量和位置的任何一致模式。
