Sturgeon C M, Seth J
UK NEQAS for Peptide Hormones and Related Substances, Department of Clinical Biochemistry, Royal Infirmary, Edinburgh, United Kingdom.
Eur J Clin Chem Clin Biochem. 1996 Sep;34(9):755-9.
External Quality Assessment schemes can provide unique insight into how current methods are performing in the field. Results from the UK National External Quality Assessment Schemes, which monitor performance of immunoassays for a number of tumour markers and peptide hormones in serum, show that in spite of considerable improvements resulting from increased assay automation, major discrepancies in results obtained are still observed. Reasons for this include poor calibration, use of antibodies of differing specificity, and vulnerability to clinically relevant interferences. Variation in quoted reference ranges is also a cause of concern. Each of these important aspects of performance will require attention if improved between-method and between-laboratory agreement is to be achieved.
外部质量评估计划可以为当前方法在该领域的表现提供独特的见解。英国国家外部质量评估计划监测血清中多种肿瘤标志物和肽类激素免疫分析的性能，其结果表明，尽管分析自动化程度提高带来了显著改善，但仍观察到所获得结果存在重大差异。原因包括校准不佳、使用特异性不同的抗体以及易受临床相关干扰影响。引用的参考范围存在差异也是一个令人担忧的问题。如果要实现方法间和实验室间更好的一致性，这些性能的重要方面都需要得到关注。
