Treatment with growth hormone increases lipoprotein(a) serum levels in children with chronic renal insufficiency.

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作者信息

Querfeld U, Haffner D, Wühl E, Wingen A M, Wolter K, Friedrich B, Michalk D V, Mehls O

出版信息

Eur J Pediatr. 1996 Oct;155(10):913. doi: 10.1007/BF02282846.

DOI:10.1007/BF02282846

PMID:8891566

Abstract

摘要

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Treatment with growth hormone increases lipoprotein(a) serum levels in children with chronic renal insufficiency.

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Plasma levels of soluble CD30 are increased in children with chronic renal failure and with primary growth deficiency and decrease during treatment with recombination human growth hormone.慢性肾功能衰竭和原发性生长发育迟缓儿童的血浆可溶性CD30水平升高，而在重组人生长激素治疗期间降低。

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本文引用的文献

Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations.生长激素缺乏的成年人接受生长激素治疗后，脂蛋白(a)和高密度脂蛋白胆固醇浓度显著升高。

Arterioscler Thromb. 1993 Feb;13(2):296-301. doi: 10.1161/01.atv.13.2.296.

Increased concentrations of serum lipoprotein (a) in response to growth hormone treatment.生长激素治疗后血清脂蛋白（a）浓度升高。

BMJ. 1993 Jun 26;306(6894):1726-7. doi: 10.1136/bmj.306.6894.1726-a.

Serum apolipoprotein(a) correlates with growth hormone levels in Chinese patients with acromegaly.在中国肢端肥大症患者中，血清载脂蛋白(a)与生长激素水平相关。

Atherosclerosis. 1993 Dec;104(1-2):183-8. doi: 10.1016/0021-9150(93)90189-2.

Lipoprotein(a) serum levels and apolipoprotein(a) phenotypes in children with chronic renal disease.慢性肾病患儿的脂蛋白(a)血清水平及载脂蛋白(a)表型

Pediatr Res. 1993 Dec;34(6):772-6. doi: 10.1203/00006450-199312000-00015.

Low dose continuously infused growth hormone results in increased lipoprotein(a) and decreased low density lipoprotein cholesterol concentrations in middle-aged men.

Clin Endocrinol (Oxf). 1994 Jul;41(1):109-16. doi: 10.1111/j.1365-2265.1994.tb03791.x.

Lipoprotein(a) is an independent risk factor for cardiovascular disease in hemodialysis patients.脂蛋白(a)是血液透析患者心血管疾病的独立危险因素。

Circulation. 1992 Aug;86(2):475-82. doi: 10.1161/01.cir.86.2.475.

Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations.载脂蛋白(a)基因占血浆脂蛋白(a)浓度变异的90%以上。

J Clin Invest. 1992 Jul;90(1):52-60. doi: 10.1172/JCI115855.

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