Denekamp J
Oncology Department, University Hospital, Umeå, Sweden.
Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):497-509. doi: 10.1016/s0360-3016(96)00314-8.
British radiobiologists have often been at the forefront in taking clinical questions into the laboratory and in taking the results back into the clinic, i.e., what is nowadays labeled as Translational Research. They have published widely and have been very active in lectures, workshops, and discussions, forming an important component of the international communication web, both within the basic science aspects and in the translation from science to medicine, and back again. Major contributions have been made at the cellular and subcellular level, and at the level of multicellular structures, both normal and malignant. The common features of the response of cells to single doses in well-defined conditions have been used to interpret the much greater complexity of tissue and tumor responses treated with repeated small doses in a fractionated course, both of photons and other radiations, with and without chemical modifiers. The many contributions to the field of cell kinetics have provided the tools with which an understanding has been gained of the latency and evolution of radiation damage in different tissues. The prolonged interest in microenvironmental gradients and compensatory responses to injury have provided a framework for designing better radiotherapy schedules, and considerable spin-off to other branches of cancer therapy.
英国放射生物学家常常站在将临床问题带入实验室并将研究结果带回临床的前沿，也就是如今所说的转化研究。他们发表了大量研究成果，并且在讲座、研讨会和讨论中非常活跃，在基础科学领域以及从科学到医学再回归科学的国际交流网络中构成了重要组成部分。在细胞和亚细胞水平以及多细胞结构（包括正常和恶性结构）层面都有重大贡献。在明确条件下细胞对单次剂量的反应的共同特征，已被用于解释在分次照射过程中，用重复小剂量光子和其他辐射（有无化学修饰剂）治疗时，组织和肿瘤反应的更大复杂性。对细胞动力学领域的诸多贡献提供了工具，借此人们得以了解不同组织中辐射损伤的潜伏期和演变过程。对微环境梯度和损伤补偿反应的长期关注为设计更好的放射治疗方案提供了框架，并对癌症治疗的其他分支产生了相当大的附带效益。
