Sadahira Y, Moriya T, Shirabe T, Matsuno T, Manabe T
Department of Pathology, Kawasaki Medical School, Kurashiki, Japan.
Pathol Int. 1996 Aug;46(8):601-4. doi: 10.1111/j.1440-1827.1996.tb03660.x.
Epstein-Barr (EB) virus-associated primary smooth muscle tumors have been reported in immunosuppressed young patients with acquired immunodeficiency syndrome (AIDS) and young people who have undergone liver transplantation. An autopsy case of EB virus-associated smooth muscle cell tumor in a 21 year old female who received immunosuppressive therapy following renal transplantation is reported. Multiple tumor nodules were present in the liver, but no primary lesion was found in any other organ. Histologically, the nodules were composed of spindle cells, positive for alpha-smooth muscle actin, which were arranged in fascicles and closely associated with vascular channels, thereby suggesting a vascular smooth muscle cell origin. EB virus infection of the tumor cells was clearly demonstrated by in situ hybridization with an EB virus-encoded RNA 1 (EBER-1) probe. The present case illustrates that EB virus infection may play some role in the development of smooth muscle tumors not only in immunocompromised young patients with liver allografts, but also in those with renal allografts.
据报道，爱泼斯坦-巴尔（EB）病毒相关的原发性平滑肌瘤出现在患有获得性免疫缺陷综合征（AIDS）的免疫抑制年轻患者以及接受肝移植的年轻人中。本文报告了一例21岁女性肾移植后接受免疫抑制治疗的EB病毒相关平滑肌瘤细胞肿瘤的尸检病例。肝脏中存在多个肿瘤结节，但在其他任何器官均未发现原发性病变。组织学上，结节由梭形细胞组成，α-平滑肌肌动蛋白呈阳性，这些细胞排列成束状并与血管通道紧密相连，从而提示血管平滑肌细胞起源。通过用EB病毒编码的RNA 1（EBER-1）探针进行原位杂交，清楚地证明了肿瘤细胞的EB病毒感染。本病例表明，EB病毒感染不仅在接受肝移植的免疫受损年轻患者中，而且在接受肾移植的患者中，可能在平滑肌瘤的发生中起一定作用。
