Honda M, Barrett G, Yoshimura N, Ikeda A, Nagamine T, Shibasaki H
Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.
Electroencephalogr Clin Neurophysiol. 1996 Sep;100(5):407-21.
We have studied event-related potentials (ERPs) during a visual paired association task with delayed discrimination in 10 normal right-handed subjects. After subjects completely memorized 4 pairs of figures during a learning period, they were presented with each cue (S1) and asked to judge whether the following figure (S2) formed one of the memorized pairs or not. A choice reaction task with delay was used for control in an attempt to identify brain activity specifically related to memory function. ERPs were recorded from 21 scalp electrodes and those occurring between the S1 and S2 presentation were analyzed. Two ERP components associated with memory function were identified in the difference waveform between the responses in the paired association task and those in the choice reaction task. One was a posterior positive component which appeared between 390 ms and 1100 ms after the S1 presentation and the other was a sustained frontal negative component which began at about 1100 ms after S1 and ended just before the S2 presentation. Both potentials were distributed predominantly on the scalp overlying the left hemisphere. It is postulated that the early posterior positive component may reflect retrieval of information from association memory, whereas the late frontal negativity may reflect retention of information in working memory.
我们对10名右利手正常受试者在视觉配对联想任务（伴有延迟辨别）期间的事件相关电位（ERP）进行了研究。在学习阶段受试者完全记住4对图形后，向他们呈现每个线索（S1），并要求他们判断随后出现的图形（S2）是否构成记忆中的一对。采用延迟选择反应任务作为对照，以试图识别与记忆功能特别相关的脑活动。从21个头皮电极记录ERP，并分析S1和S2呈现之间出现的ERP。在配对联想任务和选择反应任务的反应差异波形中识别出两个与记忆功能相关的ERP成分。一个是在S1呈现后390毫秒至1100毫秒之间出现的后部正成分，另一个是持续的额叶负成分，在S1后约1100毫秒开始，在S2呈现前结束。这两种电位主要分布在左半球上方的头皮上。据推测，早期后部正成分可能反映了从联想记忆中提取信息，而晚期额叶负性成分可能反映了工作记忆中信息的保持。
