Honda M, Barrett G, Yoshimura N, Sadato N, Yonekura Y, Shibasaki H
Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.
Exp Brain Res. 1998 Mar;119(1):103-15. doi: 10.1007/s002210050324.
Event-related potentials (ERP) and regional cerebral blood flow (rCBF) activation using 15O-labeled water associated with retrieval and retention of episodic memory were studied during a visual paired-association task with delayed response in eight healthy subjects. In both studies, the subjects memorized four pairs of figures during the learning period. They were presented with each cue (S1) and asked to judge whether the following figure (S2) formed one of the memorized pairs. In an attempt to identify brain activity related to memory function, a choice reaction task with delay was used as a behavioral control. The ERP study showed a posterior positive component in the difference waveform, which was obtained by subtracting responses in the choice reaction task from those in the paired association task, between 300 and 850 ms after S1 presentation. It was maximal at the parietal midline electrode and distributed predominantly over the left posterior quadrant of the scalp. The rCBF activation study showed a greater increase in rCBF in the right dorsolateral prefrontal cortex (Brodmann's area 46), left inferior frontal cortex (Brodmann's area 44/45), left thalamus, and bilateral cerebellar hemisphere during the paired association task as compared to the choice reaction task, which suggests a possible involvement of cerebello-thalamo-cortical circuit in the memory processing. Additionally, it is suggested that the scalp distribution of the ERP component may not necessarily represent regional cortical activation below the electrodes where such a component is observed and could indirectly represent activation in remote areas such as subcortical regions. It seems that ERP and rCBF activation may provide information about different aspects of higher brain function.
在一项针对8名健康受试者的视觉配对联想延迟反应任务中，研究了与情景记忆的提取和保持相关的事件相关电位（ERP）以及使用15O标记水的局部脑血流（rCBF）激活情况。在两项研究中，受试者在学习阶段记住了四对图形。向他们呈现每个线索（S1），并要求他们判断随后的图形（S2）是否构成记忆中的一对。为了识别与记忆功能相关的大脑活动，使用了延迟选择反应任务作为行为对照。ERP研究显示，在呈现S1后300至850毫秒之间，通过从配对联想任务中的反应减去选择反应任务中的反应获得的差异波形中存在一个后部正向成分。它在顶叶中线电极处最大，主要分布在头皮的左后象限。rCBF激活研究显示，与选择反应任务相比，在配对联想任务期间，右侧背外侧前额叶皮质（布罗德曼46区）、左侧额下皮质（布罗德曼44/45区）、左侧丘脑和双侧小脑半球的rCBF增加更大，这表明小脑 - 丘脑 - 皮质回路可能参与记忆处理。此外，有人提出，ERP成分的头皮分布不一定代表观察到该成分的电极下方的局部皮质激活，可能间接代表皮质下区域等远程区域的激活。似乎ERP和rCBF激活可能提供有关高级脑功能不同方面的信息。
