Ndukwe G, Thornton S, Fishel S, Dowell K, al-Hassan S, Hunter A
Nottingham University Research and Treatment Unit in Reproduction (NURTURE), Department of Obstetrics and Gynaecology, Queen's Medical Centre, United Kingdom.
Fertil Steril. 1996 Nov;66(5):845-7.
To determine a simple predictive test for empty follicle syndrome before oocyte retrieval.
Retrospective correlation analysis.
Patients attending Nottingham University Research and Treatment Unit, a tertiary, university-based assisted reproductive technologies (ART) program between April 1, 1994 and March 31, 1995.
PATIENT(S): Six women in whom no oocytes were retrieved after superovulation for ART (empty follicle syndrome) were compared with 11 women with successful oocyte retrieval.
INTERVENTION(S): Subcutaneous buserelin acetate plus IM hMG and hCG were used for superovulation. Oocyte retrieval was transvaginal and ultrasound guided.
MAIN OUTCOME MEASURE(S): Ultrasound measurement of follicular growth and serum E2 levels during superovulation. Serum beta-hCG levels before and 36 hours after hCG administration IM. Number of oocytes retrieved.
RESULT(S): Before hCG administration, beta-hCG was not detectable in the serum. The serum beta-hCG 36 hours after hCG was 209 +/- 16.7 mIU/mL (conversion factor to SI units, 1.0; mean +/- SEM, range 106 to 290 mIU/mL) in women with successful oocyte retrieval and 4 +/- 1.8 mIU/mL (range 0 to 9 mIU/mL) in empty follicle syndrome. This difference was significant.
CONCLUSION(S): Empty follicle syndrome is associated with very low bioavailability of beta-hCG and can be predicted by measuring serum beta-hCG level 36 hours after IM hCG administration.
在取卵前确定一种用于预测空卵泡综合征的简单检测方法。
回顾性相关性分析。
1994年4月1日至1995年3月31日期间，诺丁汉大学研究与治疗中心，一个基于大学的三级辅助生殖技术（ART）项目。
6名接受ART超排卵后未取出卵母细胞（空卵泡综合征）的女性与11名成功取出卵母细胞的女性进行比较。
皮下注射醋酸布舍瑞林加肌肉注射人绝经期促性腺激素（hMG）和人绒毛膜促性腺激素（hCG）进行超排卵。经阴道超声引导取卵。
超排卵期间卵泡生长的超声测量及血清雌二醇（E2）水平。肌肉注射hCG前及注射后36小时的血清β-hCG水平。取出的卵母细胞数量。
注射hCG前，血清中未检测到β-hCG。成功取出卵母细胞的女性，注射hCG后36小时血清β-hCG为209±16.7 mIU/mL（转换为国际单位制的换算因子为1.0；平均值±标准误，范围106至290 mIU/mL），空卵泡综合征患者为4±1.8 mIU/mL（范围0至9 mIU/mL）。差异有统计学意义。
空卵泡综合征与β-hCG的生物利用度极低有关，可通过测量肌肉注射hCG后36小时的血清β-hCG水平进行预测。
