Perloff L J, Rowlands D T, Barker C F
Ann Surg. 1977 Aug;186(2):227-32. doi: 10.1097/00000658-197708000-00018.
Segments of rat inferior vena cava were modified by proteolytic digestion and dialdehyde starch tanning in an attempt to alter their antigenic nature and increase their tensile strength. These tissues were found to retain their ability to sensitize allogeneic recipients in both the intradermal and intra-aortic positions in all 50 experimental animals. Furthermore, these grafts had a very high aneurysm formation (100%), and aneurysm rupture (54%) rate even in isogeneic recipients, suggesting that the modification procedure so damages the structural integrity of venous tissue that its use in clinical situations may have disastrous consequences. Histologic evidence of intimal thickening, elastic disruption, and often severe acute and chronic inflammation supported the gross evidence of mechanical and immunologic damage and suggests that a mild brief course of immunosuppression may be indicated in clinical trials in situation in which autogenous saphenous vein in unavailable. Although the use of prosthetic mesh support for the graft may help to avoid structural changes, the introduction of synthetic materials may offset the theoretical advantages of the venous tissue.
对大鼠下腔静脉段进行蛋白水解消化和二醛淀粉鞣制处理，试图改变其抗原性质并提高其拉伸强度。在所有50只实验动物中，发现这些组织在皮内和主动脉内位置均保留了使同种异体受体致敏的能力。此外，即使在同基因受体中，这些移植物也有非常高的动脉瘤形成率（100%）和动脉瘤破裂率（54%），这表明该修饰程序严重损害了静脉组织的结构完整性，以至于在临床情况下使用可能会产生灾难性后果。内膜增厚、弹性破坏以及常出现的严重急性和慢性炎症的组织学证据支持了机械和免疫损伤的大体证据，并表明在无法使用自体隐静脉的情况下，临床试验中可能需要进行轻度短期的免疫抑制。尽管使用人工网片支撑移植物可能有助于避免结构变化，但合成材料的引入可能会抵消静脉组织的理论优势。
