Connolly J E, Kwaan J H, Stemmer E A
Ann Surg. 1977 Sep;186(3):334-42. doi: 10.1097/00000658-197709000-00011.
Two hundred ninety patients undergoing carotid endarterectomy were reviewed. From 1968 to 1972, 188 patients had carotid endarterectomy under general anesthesia with use of a shunt and hypercarbia. Stump pressures were not recorded in this group. There were three deaths, three postoperative hemiplegias and two complications of transient limb weakness. From 1973 to 1975, 102 patients were operated on under local anesthesia with systemic Innovar and Sublimaze, normocarbia and intra-operative assessment of stump pressure. In this group there was one death, no hemiplegia, and no complications of transient limb weakness. Twenty of the 102 were shunted either on the basis of stump pressure or the loss of motor ability or consciousness on carotid clamping. Those shunted had stump pressures ranging from 10 to 70 mm Hg with a mean of 20 while those not shunted had stump pressures ranging from 20 to 85 mm Hg with a mean of 53 mm Hg. Five patients lapsed into unconsciousness despite internal carotid stump pressures of 30, 30, 34, 36 and 70 mm Hg respectively, thus requiring intraoperative shunting. This experience seriously questions the reliability of carotid stump pressure as the sole determinant to identify those patients who require intraoperative shunting. We have come full circle, back to operation under local anesthesia, since intraoperative assessment of the patient's motor ability and consciousness alone provide the only absolute criteria for assessing the need for intraoperative shunting. Since the operation can be performed with greater technical efficiency without a shunt and without the potential complications of shunting itself, it behooves the surgeon to have a reliable method of knowing when it is not required.
对290例行颈动脉内膜切除术的患者进行了回顾性研究。1968年至1972年期间,188例患者在全身麻醉下接受颈动脉内膜切除术,术中使用分流管并采用高碳酸血症策略。该组未记录残端压力。发生了3例死亡、3例术后偏瘫以及2例短暂性肢体无力并发症。1973年至1975年期间,102例患者在局部麻醉下接受手术,术中使用全身Innovar和Sublimaze,维持正常碳酸血症并对残端压力进行术中评估。该组有1例死亡,无偏瘫病例,也无短暂性肢体无力并发症。102例患者中有20例基于残端压力、颈动脉夹闭时运动能力丧失或意识丧失而进行了分流。分流患者的残端压力范围为10至70毫米汞柱,平均为20毫米汞柱;未分流患者的残端压力范围为20至85毫米汞柱,平均为53毫米汞柱。5例患者尽管颈内动脉残端压力分别为30、30、34、36和70毫米汞柱,但仍陷入昏迷,因此需要术中分流。这一经验严重质疑了将颈动脉残端压力作为确定哪些患者需要术中分流的唯一决定因素的可靠性。我们又回到了原点,重新采用局部麻醉下手术,因为仅术中评估患者的运动能力和意识就为评估术中分流需求提供了唯一的绝对标准。由于不使用分流管进行手术可以提高技术效率,且没有分流本身的潜在并发症,外科医生理应拥有一种可靠的方法来确定何时不需要分流。