Ginsburg E K, Axenovich T I, Goodman D W
Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Genet Epidemiol. 1996;13(4):355-65. doi: 10.1002/(SICI)1098-2272(1996)13:4<355::AID-GEPI4>3.0.CO;2-3.
Two methods of estimating linkage test power are proposed. The first method is based on the maximum likelihood (ML) estimate of the recombination fraction and is intended for use with a likelihood ratio test (LRT) in the form of a chi 2 or lod score. The power is estimated through a noncentral chi 2 distribution with a specially chosen noncentrality parameter. The second method uses the LRT constructed for a simple alternative hypothesis regarding the recombination fraction value. The approximate distribution of this test and a method of estimating its power is proposed. Using simulated pedigree data, the power estimates for these two methods were shown to be satisfactory. Comparisons among these two methods and the computer simulation approach of Boehnke [1986] are performed.
提出了两种估计连锁检验效能的方法。第一种方法基于重组率的最大似然（ML）估计，旨在用于卡方检验或对数优势比分形式的似然比检验（LRT）。通过具有特别选定的非中心参数的非中心卡方分布来估计效能。第二种方法使用针对重组率值的简单备择假设构建的LRT。提出了该检验的近似分布及其效能估计方法。使用模拟家系数据，结果表明这两种方法的效能估计令人满意。对这两种方法与Boehnke [1986]的计算机模拟方法进行了比较。
