免疫组织化学检测碱性成纤维细胞生长因子作为肺腺癌预后指标的研究

Immunohistochemical detection of basic fibroblast growth factor as a prognostic indicator in pulmonary adenocarcinoma.

作者信息

Takanami I, Imamura T, Hashizume T, Kikuchi K, Yamamoto Y, Yamamoto T, Kodaira S

机构信息

The First Department of Surgery, Teikyo University School of Medicine, Tokyo.

出版信息

Jpn J Clin Oncol. 1996 Oct;26(5):293-7. doi: 10.1093/oxfordjournals.jjco.a023235.

DOI:10.1093/oxfordjournals.jjco.a023235

PMID:8895667

Abstract

The expression of basic fibroblast growth factor (bFGF) was studied immunohistochemically in tissue specimens from 157 patients with pulmonary adenocarcinoma. Tumor cells that expressed bFGF were found in 89 patients (74%). The expression of bFGF was correlated with T and M in the TNM classification, disease stage and curability. The 5-year survival rate was 24% in bFGF-positive patients but 66% in bFGF-negative patients, the difference being significant (P<0.01). The 5-year survival rate of patients with stage I disease was 73% in those who were bFGF-positive but 88% in those who were bFGF-negative, the difference being significant (P<0.05). Multivariate analysis showed that the expression of bFGF was significantly related to prognosis. These findings suggest that bFGF plays an important role in tumor progression and that its expression may be a useful prognostic indicator for pulmonary adenocarcinoma.

摘要

采用免疫组织化学方法研究了157例肺腺癌患者组织标本中碱性成纤维细胞生长因子（bFGF）的表达情况。在89例患者（74%）中发现肿瘤细胞表达bFGF。bFGF的表达与TNM分类中的T和M、疾病分期及可治愈性相关。bFGF阳性患者的5年生存率为24%，而bFGF阴性患者为66%，差异有统计学意义（P<0.01）。Ⅰ期疾病患者中，bFGF阳性者的5年生存率为73%，bFGF阴性者为88%，差异有统计学意义（P<0.05）。多因素分析表明，bFGF的表达与预后显著相关。这些发现提示，bFGF在肿瘤进展中起重要作用，其表达可能是肺腺癌有用的预后指标。