Linder C, Byström P, Engel G, Auer G, Aspenblad U, Strander H, Linder S
Department of Oncology-Pathology, Karolinska Institute and Hospital, Stockholm, Sweden.
Br J Cancer. 1998 Mar;77(6):941-5. doi: 10.1038/bjc.1998.155.
We examined the localization of basic fibroblast growth factor (bFGF) in a series of human breast carcinomas using immunohistochemistry. Staining was observed in tumour cells in 15 out of 54 (28%) tumours and in the adjacent stroma in 34 out of 54 (63%) tumours examined. No correlation was observed between positive staining of these two compartments. The relationship between bFGF staining and expression of the metalloprotease stromelysin-3, and between bFGF and microvessel density, was examined. A statistically significant correlation (P < 0.003) was observed between bFGF staining of the stromal compartment and high expression of stromelysin-3 (ST-3; MMP-11) metalloprotease mRNA by stromal cells. In contrast, no correlation was observed between bFGF and intratumour microvessel density (IMD). These results raise the possibility that bFGF may be involved in the induction of stromelysin-3 mRNA expression in breast cancer stroma.
我们采用免疫组织化学方法检测了一系列人类乳腺癌中碱性成纤维细胞生长因子（bFGF）的定位。在54个肿瘤中的15个（28%）肿瘤的肿瘤细胞中观察到染色，在54个检测肿瘤中的34个（63%）肿瘤的邻近基质中观察到染色。这两个区域的阳性染色之间未观察到相关性。研究了bFGF染色与金属蛋白酶基质溶解素-3表达之间的关系，以及bFGF与微血管密度之间的关系。在基质区域的bFGF染色与基质细胞中基质溶解素-3（ST-3；MMP-11）金属蛋白酶mRNA的高表达之间观察到统计学上显著的相关性（P < 0.003）。相比之下，bFGF与肿瘤内微血管密度（IMD）之间未观察到相关性。这些结果提示bFGF可能参与乳腺癌基质中基质溶解素-3 mRNA表达的诱导。
