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相似文献

1
Biologically active macromolecular forms of oxytocin. [8-Lysine]oxytocin as a suitable ligand.催产素的生物活性大分子形式。[8-赖氨酸]催产素作为一种合适的配体。
Biochem J. 1977 Jul 1;165(1):43-7. doi: 10.1042/bj1650043.
2
Combined high oxytocic with negligible antidiuretic and pressor activities in multisubstituted oxytocins.在多取代催产素中，结合了高催产活性以及可忽略不计的抗利尿和升压活性。
J Med Chem. 1977 Apr;20(4):492-5. doi: 10.1021/jm00214a006.
3
Fluorescent, photoaffinity, and biotinyl analogs of oxytocin.催产素的荧光、光亲和及生物素化类似物。
Peptides. 1988 Jul-Aug;9(4):783-6. doi: 10.1016/0196-9781(88)90122-2.
4
A ureido group containing analogue of oxytocin comprising eight amino acid residues.
J Med Chem. 1978 Mar;21(3):306-8. doi: 10.1021/jm00201a017.
5
Study of pituitary hormone analogs for their inhibitory properties and resistance to carboxamidopeptidases: (9-L-proline)oxytocin, (9-L-glutamic acid)oxytocin, and (8-L-lysine,9-glycine methylamide)oxytocin.垂体激素类似物的抑制特性及其对羧肽酶抗性的研究：（9-L-脯氨酸）催产素、（9-L-谷氨酸）催产素和（8-L-赖氨酸，9-甘氨酸甲酰胺）催产素。
J Med Chem. 1974 Dec;17(12):1294-8. doi: 10.1021/jm00258a013.
6
Synthesis and some pharmacological properties of [4-threonine,7-sarcosine]oxytocin, a peptide with high oxytocic potency, and of [4-threonine,7-N-methylalanine]oxytocin.
J Med Chem. 1983 Dec;26(12):1786-7. doi: 10.1021/jm00366a028.
7
(1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)-8-lysine-vasopressin and (1-beta-mercapto-beta,beta-diethylpropionic acid,4-leucine)oxytocin, compounds possessing antihormonal properties.（1-β-巯基-β，β-二乙基丙酸，4-亮氨酸）-8-赖氨酸-加压素和（1-β-巯基-β，β-二乙基丙酸，4-亮氨酸）催产素，具有抗激素特性的化合物。
J Med Chem. 1974 Sep;17(9):969-72. doi: 10.1021/jm00255a012.
8
Oxytocin and lysine-vasopressin with N5,N5-dialkylglutamine in the 4 position: effect of introducing sterically hindered groups into the hydrophilic cluster of neurohypophyseal hormones.4位带有N5,N5 - 二烷基谷氨酰胺的催产素和赖氨酸加压素：将空间位阻基团引入神经垂体激素亲水簇的效果
J Med Chem. 1980 Feb;23(2):213-7. doi: 10.1021/jm00176a020.
9
Synthesis and some pharmacological properties of [1-(L-2-hydroxy-3-mercaptopropanoic acid), 4-threonine]oxytocin (hydroxy [4-thr]oxytocin), a peptide with strikingly high oxytocic potency and of [1-(L-2-hydroxy-3-mercaptopropanoic acid)]oxytocin (hydroxy-oxytocin).
J Med Chem. 1976 Mar;19(3):376-80. doi: 10.1021/jm00225a007.
10
[1-Beta-mercapto-beta,beta-pentamethylenepropionic acid]oxytocin, a potent inhibitor of oxytocin.[1-巯基-β,β-五亚甲基丙酸]催产素，一种强效催产素抑制剂。
J Med Chem. 1975 Mar;18(3):284-7. doi: 10.1021/jm00237a015.

本文引用的文献

1
A highly potent analogue of oxytocin, desamino-oxytocin.一种高效的催产素类似物，去氨基催产素。
J Biol Chem. 1962 May;237:1563-6.
2
CELLULAR AND MOLECULAR ASPECTS OF THE ANTIDIURETIC ACTION OF VASOPRESSINS AND RELATED PEPTIDES.血管加压素及相关肽类抗利尿作用的细胞与分子层面研究
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A RAPID PERMETHYLATION OF GLYCOLIPID, AND POLYSACCHARIDE CATALYZED BY METHYLSULFINYL CARBANION IN DIMETHYL SULFOXIDE.二甲基亚砜中由甲亚磺酰基碳负离子催化的糖脂和多糖的快速全甲基化反应。
J Biochem. 1964 Feb;55:205-8.
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The use of cyanate for the determination of NH2-terminal residues in proteins.用氰酸盐测定蛋白质中的氨基末端残基。
J Biol Chem. 1963 Jan;238:214-26.
5
Effect of magnesium ion on the response of the rat uterus to neurohypophysial hormones and analogues.镁离子对大鼠子宫对神经垂体激素及其类似物反应的影响。
Endocrinology. 1960 Mar;6:451-7. doi: 10.1210/endo-66-3-451.
6
Lysine-vasotocin, a synthetic analogue of the posterior pituitary hormones containing the ring of oxytocin and the side chain of lysine-vasopressin.赖氨酸 - 血管紧张素，一种后叶垂体激素的合成类似物，含有催产素的环和赖氨酸 - 加压素的侧链。
J Biol Chem. 1961 Mar;236:778-80.
7
Synthesis of oxytocin by the nitrophenyl ester method.通过硝基苯基酯法合成催产素。
Nature. 1959 May 9;183(4671):1324-5. doi: 10.1038/1831324b0.
8
Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides.通过卤化氰将肽和蛋白质与多糖进行化学偶联。
Nature. 1967 Jun 24;214(5095):1302-4. doi: 10.1038/2141302a0.
9
[Improved synthesis of etert-butyloxycarbonyl-amino acids through pH stable reactions].[通过pH稳定反应改进叔丁氧羰基氨基酸的合成]
Justus Liebigs Ann Chem. 1967;702:188-96. doi: 10.1002/jlac.19677020123.
10
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.用于检测肽固相合成中游离末端氨基的颜色测试。
Anal Biochem. 1970 Apr;34(2):595-8. doi: 10.1016/0003-2697(70)90146-6.

催产素的生物活性大分子形式。[8-赖氨酸]催产素作为一种合适的配体。

Biologically active macromolecular forms of oxytocin. [8-Lysine]oxytocin as a suitable ligand.

作者信息

Snell C R, Smyth D G

出版信息

Biochem J. 1977 Jul 1;165(1):43-7. doi: 10.1042/bj1650043.

DOI:10.1042/bj1650043
PMID:889573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1164866/
Abstract

[8-Lysine]oxytocin was synthesized on a solid support and possessed an oxytocic activity of 100 +/- 6 units mumol on the isolated rat uterus. The epsilon-carbamoyl, epsilon-3-carboxypropionyl and epsilon-3-carboxybutryl derivatives were prepared and had uterotonic activities of 400, 55 and 50 units/mumol respectively. [8-Lysine]oxytocin was coupled unambiguously through the epsilon-amino group to the carboxyl groups of carboxymethylated dextrans or epsilon-3-carboxypropionly-gelatin. The macromolecular oxytocins were water-soluble and retained signigicant oxytocic activity. [8-Lysine]oxytocin should prove a useful ligand for affinity chromatography of oxytocin-binding proteins.

摘要

[8-赖氨酸]催产素在固相载体上合成，对离体大鼠子宫具有100±6单位/微摩尔的催产活性。制备了ε-氨基甲酰、ε-3-羧基丙酰和ε-3-羧基丁酰衍生物，其子宫收缩活性分别为400、55和50单位/微摩尔。[8-赖氨酸]催产素通过ε-氨基与羧甲基化葡聚糖或ε-3-羧基丙酰明胶的羧基明确偶联。大分子催产素可溶于水，并保留显著的催产活性。[8-赖氨酸]催产素应可成为用于催产素结合蛋白亲和层析的有用配体。