Walden J, Hesslinger B, van Calker D, Berger M
University of Freiburg, Department of Psychiatry and Psychotherapy, Germany.
Pharmacopsychiatry. 1996 Sep;29(5):193-5. doi: 10.1055/s-2007-979570.
The new antiepileptic lamotrigine has been shown to be effective in the treatment of focal epilepsies with or without secondary generalization and has also been suggested to be efficacious in the treatment and prophylaxis of affective disorders. Therefore, we analyzed its possible benefit in a patient with refractory bipolar affective disorder. Lamotrigine (up to 150 mg/d) was added to valproate (2700 mg/d), substituting previously administered neuroleptics. A considerable improvement of the patient's condition was achieved several days after the beginning of lamotrigine co-administration, and lasted over the total follow-up period of more than one year. The plasma concentrations after total remission were in the range of 1.9 to 6.2 mg/l for lamotrigine and 57.1 to 95.2 mg/l for valproate. This positive action of lamotrigine is discussed in the context of the drug's elementary effects on sodium and calcium channels.
新型抗癫痫药物拉莫三嗪已被证明对伴有或不伴有继发性全面发作的局灶性癫痫有效，并且也有人提出它在情感障碍的治疗和预防中也有疗效。因此，我们分析了其对一名难治性双相情感障碍患者可能带来的益处。在丙戊酸盐（2700毫克/天）的基础上加用拉莫三嗪（剂量高达150毫克/天），停用先前使用的抗精神病药物。在开始联合使用拉莫三嗪几天后，患者的病情有了显著改善，并在超过一年的整个随访期内持续存在。完全缓解后的血浆浓度，拉莫三嗪为1.9至6.2毫克/升，丙戊酸盐为57.1至95.2毫克/升。本文结合拉莫三嗪对钠通道和钙通道的基本作用，讨论了其积极作用。
