肿瘤大小对Lewis肺癌缺氧分数及治疗敏感性的影响
Influence of tumour size on hypoxic fraction and therapeutic sensitivity of Lewis lung tumour.
作者信息
Stanley J A, Shipley W U, Steel G G
出版信息
Br J Cancer. 1977 Jul;36(1):105-13. doi: 10.1038/bjc.1977.160.
Abstract
Radiation survival curves for Lewis lung tumours in the lungs ranging in size from 0-5 to 20 mm3 have been obtained, and a size-dependent variation in hypoxic fraction was found. Cell-survival studies following treatment of various sizes of s.c. tumours indicated that the effects of 60Co gamma-rays and the chemotherapeutic agents 1,3-bas(2-chloroethyl)-1-nitrosourea (BCNU) and cyclophosphamide are all size-dependent. Large pulmonary nodules which had regressed but had not been cured by cyclophosphamide regrew with a radiosensitivity that was characteristic of previously untreated tumours. The results give additional experimental support to the clinical interest in early adjuvant therapy of micrometastases, and sequential combined modality therapy for larger tumours.
摘要
已获得大小在0.5至20立方毫米之间的Lewis肺癌在肺部的辐射存活曲线，并发现了缺氧分数的大小依赖性变化。对各种大小的皮下肿瘤进行治疗后的细胞存活研究表明，60Coγ射线以及化疗药物1,3-双(2-氯乙基)-1-亚硝基脲(BCNU)和环磷酰胺的作用均与大小有关。经环磷酰胺治疗后已消退但未治愈的大肺结节重新生长，其放射敏感性具有先前未治疗肿瘤的特征。这些结果为微转移早期辅助治疗以及较大肿瘤的序贯联合治疗的临床研究提供了更多实验支持。
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