大鼠体内甲基丙烯酸甲酯的代谢情况
Fate of methyl methacrylate in rats.
作者信息
Bratt H, Hathway D E
出版信息
Br J Cancer. 1977 Jul;36(1):114-9. doi: 10.1038/bjc.1977.161.
Up to 88% of a single dose of methyl[14C]methacrylate in rats is expired as 14CO2 in 10 days (65% in 2 h), irrespective of the route of administration and of the specific labelling of the propylene residue of the molecule. The implications of this observation, and of the excretion of small amounts of [14C]methylmalonate, [14C]-succinate and probably of [14C]beta-hydroxyisobutyrate and 2-formylpropionate, and of the formation of [14C] normal, physiological metabolites that may be accounted for by anabolism both from 14CO2 and from [14C]acetate emergent from the citric acid cycle, are that the metabolic pathway concerned involves intermediary metabolism and relates to mitochondrial function. Present findings are discussed in relation to the imputations of a report of carcinogenic risk.
大鼠单次注射甲基[¹⁴C]甲基丙烯酸酯后，高达88%的剂量会在10天内以¹⁴CO₂的形式排出（2小时内排出65%），这与给药途径以及分子中丙烯残基的特定标记无关。这一观察结果，以及少量[¹⁴C]甲基丙二酸、[¹⁴C]琥珀酸，可能还有[¹⁴C]β-羟基异丁酸和2-甲酰丙酸的排泄，以及由¹⁴CO₂和柠檬酸循环产生的[¹⁴C]乙酸盐通过合成代谢形成的[¹⁴C]正常生理代谢物，都表明相关的代谢途径涉及中间代谢且与线粒体功能有关。本文结合一份关于致癌风险报告的指控对当前研究结果进行了讨论。
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