Kültürsay H, Can L, Payzin S, Türkoğlu C, Altintiğ A, Akin M, Akilli A
Ege University, medical School, Department of Cardiology, Izmir, Turkey.
Heart Vessels. 1996;11(3):165-8. doi: 10.1007/BF01745175.
A 34-year-old man presenting with angina both at rest and on exertion was investigated. He developed severe ST segment elevation and a brief period of ventricular tachycardia during an exercise tolerance test. On coronary angiography, 60% fixed luminal narrowing was observed in the proximal left anterior descending coronary artery and a severe spasm developed at this site, leading to temporary total occlusion of the vessel. Successful coronary angioplasty (PTCA) was performed on this lesion, with a residual 15% narrowing. However, the patient had a recurrence of angina 3 weeks later, despite being administered high doses of nitrate and calcium antagonist. During control angiography, the lesion severity was unchanged, but spasm developed again following contrast injection. At this time, a Palmaz-Schatz stent was implanted. Calcium antagonist, nitrate, Ticlopidine and low molecular weight heparin therapy was started. There was no recurrence of symptoms during a 3-month follow-up. The exercise tolerance test, and myocardial perfusion scintigraphy findings were normal and the stent was patent without restenosis at the end of the 3-month follow-up. Intracoronary stent implantation for persistent coronary spasm refractory to conventional medical therapy can be considered a feasible and attractive treatment modality for the control of symptoms.
对一名34岁静息和运动时均出现心绞痛的男性患者进行了检查。他在运动耐量试验期间出现严重的ST段抬高和短暂的室性心动过速。冠状动脉造影显示,左前降支冠状动脉近端有60%的固定管腔狭窄,且该部位出现严重痉挛,导致血管暂时完全闭塞。对该病变成功进行了冠状动脉血管成形术(PTCA),残余狭窄为15%。然而,尽管给予了高剂量的硝酸盐和钙拮抗剂,患者在3周后仍复发心绞痛。在对照血管造影期间,病变严重程度未改变,但注射造影剂后再次出现痉挛。此时,植入了Palmaz-Schatz支架。开始使用钙拮抗剂、硝酸盐、噻氯匹定和低分子量肝素治疗。在3个月的随访期间没有症状复发。运动耐量试验和心肌灌注闪烁扫描结果正常,3个月随访结束时支架通畅,无再狭窄。对于常规药物治疗无效的持续性冠状动脉痉挛,冠状动脉内支架植入术可被视为一种控制症状的可行且有吸引力的治疗方式。