Leisch F, Schützenberger W, Kerschner K, Herbinger W
Br Heart J. 1986 Oct;56(4):341-5. doi: 10.1136/hrt.56.4.341.
Nineteen (86%) of 22 patients with variant angina and important coronary stenoses (greater than 60%) had successful percutaneous transluminal coronary angioplasty. The acute complications in two patients were not caused by coronary spasms but by dissection with disturbance of perfusion. One of these two patients required a coronary bypass graft; the other was treated conservatively. Myocardial infarction developed in both patients. Despite long term administration of nifedipine (30-80 mg daily), restenoses occurred within six months (on average after 10 weeks) in nine patients with symptoms and one without. In four patients the restenoses exceeded the degree of stenosis before angioplasty. Five patients were revascularised by surgical means. Vessels in three out of four patients were later successfully dilated. After a mean period of observation of 24 months (6-51 months) 18 of the 19 patients are symptom free and do not require medication. The results confirm that angioplasty is an effective method of treating patients with variant angina and important coronary stenoses. The problem of the high frequency of restenosis, however, remains unresolved.
22例变异型心绞痛且冠状动脉严重狭窄（超过60%）的患者中，19例（86%）成功接受了经皮腔内冠状动脉成形术。2例患者的急性并发症并非由冠状动脉痉挛引起，而是由伴有灌注障碍的夹层形成所致。这2例患者中，1例需要进行冠状动脉搭桥手术；另1例接受了保守治疗。2例患者均发生了心肌梗死。尽管长期服用硝苯地平（每日30 - 80毫克），9例有症状患者和1例无症状患者在6个月内（平均10周后）出现了再狭窄。4例患者的再狭窄程度超过了血管成形术前的狭窄程度。5例患者通过手术进行了血运重建。4例患者中有3例的血管后来成功扩张。经过平均24个月（6 - 51个月）的观察期后，19例患者中有18例无症状且无需药物治疗。结果证实，血管成形术是治疗变异型心绞痛且冠状动脉严重狭窄患者的有效方法。然而，再狭窄发生率高的问题仍未得到解决。
