Opalchenova G, Dyulgerova E, Petrov O E
National Drug Institute, Sofia, Bulgaria.
J Biomed Mater Res. 1996 Nov;32(3):473-9. doi: 10.1002/(SICI)1097-4636(199611)32:3<473::AID-JBM22>3.0.CO;2-G.
This paper discusses the results of an experimental study on the effect of biphase calcium phosphate ceramics (BCPC) on laboratory-isolated polyresistant Gram-negative bacteria. Monitoring of this effect in a dynamical regimen was carried out upon Enterobacter cloacae 313, Klebsiella pneumoniae 227, Serratia marcescens 206, Klebsiella oxytoca 202, as well as on the standard strain Klebsiella pneumoniae 52145 (Institute Pasteur, Paris). The results show a significant antimicrobial effect of the ceramics. Antimicrobial properties are manifested during direct contact with BCPC and these depend on the quantity and grain size of the particles, as well as on the microbiological characteristics of the test microorganisms, and particularly on their cell size.
本文讨论了双相磷酸钙陶瓷（BCPC）对实验室分离的多重耐药革兰氏阴性菌影响的实验研究结果。在动态条件下，对阴沟肠杆菌313、肺炎克雷伯菌227、粘质沙雷氏菌206、产酸克雷伯菌202以及标准菌株肺炎克雷伯菌52145（巴黎巴斯德研究所）进行了该效应的监测。结果显示该陶瓷具有显著的抗菌作用。抗菌特性在与BCPC直接接触时表现出来，并且这些特性取决于颗粒的数量和粒径，以及测试微生物的微生物学特征，特别是它们的细胞大小。
