MacDonald R G, MacDonald H N
Br J Obstet Gynaecol. 1977 Jun;84(6):427-33. doi: 10.1111/j.1471-0528.1977.tb12617.x.
Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and associated haematological parameters were measured throughout the normal menstrual cycle, in each trimester of pregnancy and on the third day post partum. There was no significant change during the menstrual cycle but the 2,3-DPG concentration was increased early in pregnancy, and thereafter gradually decreased. Although other metabolic changes are likely to contribute to the increase in 2,3-DPG concentration, it is concluded that 'functional anaemia', secondary to increased oxygen demand, is a more important stimulus than the decrease in haemoglobin concentration. The implications of a decreased oxygen affinity of haemoglobin, secondary to the rise in 2,3-DPG concentration, are discussed in relation to anaemia and blood transfusion in pregnancy.
在整个正常月经周期、孕期各阶段及产后第三天，对红细胞2,3 -二磷酸甘油酸（2,3 - DPG）及相关血液学参数进行了测量。月经周期中无显著变化，但孕期早期2,3 - DPG浓度升高，此后逐渐下降。尽管其他代谢变化可能导致2,3 - DPG浓度升高，但得出的结论是，继发于氧需求增加的“功能性贫血”是比血红蛋白浓度降低更重要的刺激因素。本文结合孕期贫血和输血，讨论了因2,3 - DPG浓度升高导致血红蛋白氧亲和力降低的影响。
