Selvaag E, Thune P
Department of Dermatology, Ullevaal Hospital, University of Oslo, Norway.
Photodermatol Photoimmunol Photomed. 1996 Apr;12(2):79-83. doi: 10.1111/j.1600-0781.1996.tb00179.x.
The oral antidiabetics glibenclamide and glipizide, and the diuretics bendroflumethiazide and furosemide, all sulphonamide derived drugs, were investigated in vitro for phototoxic properties. Irradiation with broad-band UV induced phototoxic inhibition of colony forming ability in cell cultures. During irradiation, the substances lost one absorption maximum in the UVA region, demonstrated by UV spectroscopy. These findings correlate well with the UV applied, the action spectrum being in the UVA region. Photoproducts detected during and after irradiation showed a decomposition of the substances due to ionization and fragmentation. Incubation of these preirradiated drugs with the cell cultures revealed no phototoxic effects.
对口服抗糖尿病药物格列本脲和格列吡嗪以及利尿剂苄氟噻嗪和呋塞米这几种均为磺酰胺衍生药物进行了体外光毒性特性研究。用宽带紫外线照射可诱导细胞培养物中集落形成能力的光毒性抑制。在照射过程中，通过紫外光谱法证明这些物质在UVA区域失去了一个吸收最大值。这些发现与所施加的紫外线密切相关，作用光谱在UVA区域。照射期间和照射后检测到的光产物显示出这些物质因电离和碎片化而分解。将这些预先照射过的药物与细胞培养物一起孵育未显示出光毒性作用。
