Selvaag E
Department of Dermatology, Ullevaal Hospital, University of Oslo, Norway.
Photodermatol Photoimmunol Photomed. 1996 Dec;12(6):227-32. doi: 10.1111/j.1600-0781.1996.tb00209.x.
A number of sulphonamide-derived oral antidiabetics and diuretics were investigated for phototoxic properties, using different sources of light, by means of a photohemolysis test. Photohemolysis was obtained after irradiation with UVA, visible light and solar simulating irradiation. No phototoxic properties were seen when the test samples were exposed to UVB alone. The most prominent hemolysis was induced by solar simulating irradiation. When exposing the the test samples to UVB prior to the subsequently applied UVA, visible light or solar simulating irradiation, a significantly higher hemolysis was detected compared with the previous tests, suggesting photoaugmentation effects in this model.
通过光溶血试验，利用不同光源，对多种磺酰胺衍生的口服抗糖尿病药物和利尿剂的光毒性特性进行了研究。用UVA、可见光和模拟太阳辐射照射后出现了光溶血现象。当测试样品仅暴露于UVB时，未观察到光毒性特性。模拟太阳辐射诱导的溶血最为显著。在随后施加UVA、可见光或模拟太阳辐射之前，先将测试样品暴露于UVB，与之前的测试相比，检测到溶血明显更高，表明该模型中存在光增强效应。
