Selvaag E
Department of Dermatology, Ullevaal Hospital, University of Oslo, Norway.
Arzneimittelforschung. 1997 Jan;47(1):97-100.
A number of sulphonamide derived oral antidiabetics (chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide and tolbutamide) and diuretics (bemetizide, bendroflumethiazide, benzylhydrochlorothaizide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, piretanide, polythiazide, trichlormethiazide and xipamide) were investigated for phototoxicity in a cell culture model. Cell death dependent on UVA fluence and test substance concentration was observed in the presence of the oral antidiabetics glibenclamide and gliquidone, as well as the diuretics bemetizide, bendroflumethiazide, benzylhydroxhlorothiazide, bumetanide, butizide, hydrochlorothiazide, hydroflumethiazide, piretanide, polythiazide and trichlormethiazide. Bendroflumethiazide was phototoxic at 5 x 10(-5) mol/l and higher concentrations, bemetizide, benzylhydrochlorothiazide, bumetanide and hydroflumethiazide were phototoxic at 2.5 x 10(-4) mol/l and higher concentrations, and the oral antidiabetics glibenclamide and gliquidone as well as the diuretics butizide, hydrochlorothiazide, piretanide, polythiazide and trichlormethiazide were phototoxic at 5 x 10(-4) mol/l and higher concentrations. The oral antidiabetics chlorpropamide, glipizide, glymidine, tolazamide and tolbutamide as well as the diuretics chlortalidone, furosemide, indapamide and xipamide did not induce phototoxicity in this assay.
在细胞培养模型中，对多种磺酰胺衍生的口服抗糖尿病药物（氯磺丙脲、格列本脲、格列吡嗪、格列喹酮、格列米脲、妥拉磺脲和甲苯磺丁脲）和利尿剂（苄氟噻嗪、苄氟噻嗪、苄氢氯噻嗪、布美他尼、布噻嗪、氯噻酮、呋塞米、氢氯噻嗪、氢氟噻嗪、吲达帕胺、吡咯他尼、多噻嗪、三氯噻嗪和希帕胺）进行了光毒性研究。在口服抗糖尿病药物格列本脲和格列喹酮以及利尿剂苄氟噻嗪、苄氟噻嗪、苄氢氯噻嗪、布美他尼、布噻嗪、氢氯噻嗪、氢氟噻嗪、吡咯他尼、多噻嗪和三氯噻嗪存在的情况下，观察到细胞死亡与紫外线A（UVA）通量和受试物质浓度有关。苄氟噻嗪在5×10⁻⁵摩尔/升及更高浓度下具有光毒性，苄氟噻嗪、苄氢氯噻嗪、布美他尼和氢氟噻嗪在2.5×10⁻⁴摩尔/升及更高浓度下具有光毒性，口服抗糖尿病药物格列本脲和格列喹酮以及利尿剂布噻嗪、氢氯噻嗪、吡咯他尼、多噻嗪和三氯噻嗪在5×10⁻⁴摩尔/升及更高浓度下具有光毒性。口服抗糖尿病药物氯磺丙脲、格列吡嗪、格列米脲、妥拉磺脲和甲苯磺丁脲以及利尿剂氯噻酮、呋塞米、吲达帕胺和希帕胺在该试验中未诱导光毒性。
