Banzett R B
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Respir Physiol. 1996 Aug;105(1-2):47-55. doi: 10.1016/0034-5687(96)00042-4.
The time course of change in 'air hunger', the uncomfortable urge to breathe, was assessed following sudden increases and decreases in PETCO2. Healthy normal men and women were mechanically ventilated at constant tidal volume and frequency, and were required to rate the perceived intensity of air hunger every 10-15 sec. PETCO2 was changed by altering FICO2 unbeknownst to the subject. Air hunger changed to its new level following steps with a median time constant of about 50 sec during hyperoxia. Changes in air hunger following PETCO2 steps were slightly faster when background gas was slightly hypoxic. Although the present results are consistent with the hypothesis that air hunger and ventilatory drive share the same receptors and central neural processes, analysis of dynamic response is probably not sensitive enough to disprove the hypothesis.
在呼气末二氧化碳分压（PETCO2）突然升高和降低之后，对“空气饥饿感”（即呼吸的不适冲动）的变化时间过程进行了评估。健康的正常男性和女性以恒定的潮气量和频率进行机械通气，并被要求每10 - 15秒对感觉到的空气饥饿感强度进行评分。PETCO2通过改变吸入二氧化碳分数（FICO2）来改变，而受试者并不知晓。在高氧期间，空气饥饿感在PETCO2改变后达到新水平的中位时间常数约为50秒。当背景气体略呈低氧时，PETCO2改变后空气饥饿感的变化略快。尽管目前的结果与空气饥饿感和通气驱动共享相同受体及中枢神经过程这一假设一致，但动态反应分析可能不够灵敏，无法反驳该假设。
